Ayurvedic Management of Kikkisa (Striae garavidarum)

The woman is most beautiful creation of almighty God. Woman is very conscious about their beauty. So when she sees any mark on the body, she becomes anxious. Ayurveda is an ancient science of indigenous medicine, it is not only a medical science but it is an art of living in human beings. Kikkisa is a one type of skin ailment that occurs during pregnancy and mentioned by various Acharyas under the heading of Garbhini Vyapada (disorders of pregnancy). Striae garavidarum especially appeared during second trimester of pregnancy and it may cause psychological distress in women. Bahya and Abhyantara Shamana Dravyas are used in the Chikitsa of Kikkisa

Social Media Challenge: Sentiment Analysis in Maruti Suzuki India Ltd.

The growth of social media platforms and its users has shown a stupendous growth since 2005. According to a survey done by Social Media Examiner with social media marketers, 83% of the respondents agreed that social media is the need of the hour for organization because customers use it for giving their opinion about the product/service the organization offers. It’s a proven fact that social media distributes information much faster than traditional word-of-mouth. Thus, it’s more important than ever for organisations to monitor what is being said about their product/service across all social media networks. Social media monitoring requires gaining insight for the positive, negative or neutral opinion given by the users or in other words gaining insight for sentiment analysis. On the basis of sentiment analysis, organisations can identify the opportunities, implement novel strategies, adjust campaigns duly and improve their brand image leveraging the power of social media. This study focuses on the challenges faced by India’s leading automobile company, Maruti Suzuki India Ltd. during the process of sentiment analysis

A nanny model for intrinsically disordered proteins

Proteins without a well-defined tertiary structure are intrinsically unstable and are prone to degradation by the 20S proteasome. In my thesis, I investigate the protection mechanisms of intrinsically disordered (ID) protein regions via protein interactions using the AP-1 complex as a model system. AP-1 is composed of c-Fos and c-Jun proteins, out of which c-Fos has a shorter half-life than c-Jun. Interactions by c-Jun were shown to prolong the lifetime of c-Fos, leading to the proposal of the nanny model. This mechanism, where weak protein interactions protect unstructured regions without an induced folding, however, has never been probed directly. Here I investigate the nature of the interactions of c-Fos with c-Jun and how changes in disordered regions contribute to changes in half-life. I use mutational analysis to provide insight into changes in degradation rate as a function of the binding affinity in the bound form with c-Jun. I designed five mutants at the structured regions of c-Fos affecting specific contact sites (L165V, L172V) or charge separation (E175D, E189D, K190R) with c-Jun of which both modulate c-Fos turnover, proportionally to their impact on binding affinity. Interestingly, removal of the disordered region in the complex beyond the structured domain is observed to decrease c-Fos half-life indicating their role in the stability of the complex. The finding suggests that the protein turnover by the 20S proteasome can be fine-tuned by both structured and unstructured regions between c-Fos and c-Jun, consistent with the proposed 'nanny' model. These results highlight a novel aspect of disordered regions present in the bound form (fuzziness) in regulating protein half-life via fine-tuning the association rates between the two proteins. First, it demonstrates that the protection of disordered regions from degradation could be achieved without inducing a stable structure as confirmed by ECD spectroscopy. Binding to a partner generates a fuzzy complex, where fuzzy regions in protein complexes can serve as a nonspecific transient anchor. Second, the protection of disordered regions can be achieved with many binding configurations in the bound state without decreasing the conformational entropy. Thus, the protective role of fuzzy interactions from the 20S proteasome could also provide a possible explanation for how low-complexity sequence motifs involved in higher-order protein structures might serve as selective inhibitors of proteolysis.d

Measuring the Influence and Intensity of Customer’s Sentiments in Facebook and Twitter

Organisations these days are actively using social media platforms to engage with potential and existing customers and monitor what they say about the organisation’s product or service. The most important area within social media monitoring lies in how to gain insight for sentiment analysis. Sentiment analysis helps in effective evaluation of customer’s sentiments in real time and takes on a special meaning in the context of online social networks like Twitter and Facebook, which collectively represent the largest online forum available for public opinion. Sentiment Analysis is not about retrieving and analyzing the analytics purely on the basis of positive, negative or neutral sentiment. It is imperative to assess the influencers of the sentiments in terms of Retweet and Share option used by them on Twitter and Facebook platform respectively. Measuring the intensity is other important aspect of sentiment analysis process. What kind of nouns, adjectives, verbs and adverbs are used in the opinion across the Twitter and Facebook platform matters as well since it exhibits the intensity of the underlying emotion in the text written. This study was conducted to propose a framework to identify and analyse the positive and negative sentiments present in Twitter and Facebook platforms and an algorithm was prepared to measure the intensity and influence of the positive, negative sentiment in particular using the document and sentence level analysis technique

A CONCEPTUAL STUDY OF AYURVEDIC MANAGEMENT OF MUKHADUSHIKA W.S.R TO ACNE VULGARIS: A REVIEW

Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and non-inflammatory (comedones, open and closed) lesions. Propionibacterium acnes and Staphylococcus epidermidis are common pus-forming microbes responsible for the development of various forms of, acne vulgaris. In Ayurveda it is described under the Mukhadushika or Yuvanapidika which is type of Kshudraroga. It is generally androgenic disease which is seen at puberty on both sexes. Today due to imbalanced life style (Apathy) and heavy pollution this problem increasing day by day. Guru Aahar, Madhya, Anidra, Upvas, Krodha, Santap, Savbhav are some causative factor of Mukhadushika. It is generally due to vitiation of Vata, Kapha and Rakta having Shalmali like eruption on face. In Ayurveda for the treatment of Mukhadushika (Kshudraroga) mainly two type of Chikitsa are described i.e. Shodhana chikitsa and Shamana chikitsa. As described by various Acharya the Shodhana chikitsa includes Vamana, Nasya and Shiravedha. The Shamana chikitsa includes various types of Lepa and Pralepa. Vamana Virechana, Nasya and Shira vedha will be beneficial along with some internal and external herbal, Mineral and herbominaral Ayurvedic drugs. In this review article, we tried to highlight Ayurvedic Management of Acne vulgaris (Mukhadushika) mentioned in Ayurveda with scientific justification

A study for the Assessment of Nutritional Deficiency Status of the School Going Girls

Nutrient deficiencies are prevalent worldwide. Nutritional status refers to a person's overall health, which is impacted by nutrient intake and use in the body. Children between the ages of 6 and 12 are commonly regarded to be of school age, and this might be a second chance to make up on growth. Children's nutritional condition reflects not only the family's financial position and community's social well-being but also the health-care system's productivity and the effect on the surroundings. The present study reveals that the school going girls are suffering from different nutritional deficiencies like- anaemia, underweight, overweight, obesity, stunting, iodine deficiency etc. These deficiencies are emerging health problems and become the major epidemic cause of serious health problems in India. Children's diets in India, like those in many other wealthy nations, are often imbalanced, with an overabundance of calories and protein and insufficient amounts of numerous minerals and vitamins

Terrain Specific Real Time Pixelated Camouflage Texture Generation & its Impact Assessment

“Camouflage” is a natural or nature identical phenomenon where the sensory route of vision is delayed toavoid visual detection. Reducing detection capability and hiding in the background environment is critical for Army vehicles, equipment, and soldiers. This research aims to implement a process that will generate digital camouflage patterns specific to the terrain. The adapted digital pattern helps an object blend symmetrically into the background environment. Pixelated textures combine macro and micro designs that blend with ambient shrubs, trees, branches, and shadows. The technique presented in this paper consists of the following main modules: terrain classification model, pixelated camouflage texture generation, and texture evaluation. Experiments have been conducted to detect camouflage objects in the scene to evaluate the performance of the resultant camouflage texture generated for a natural environment. Photo simulation and saliency maps for hidden object detection have been used to evaluate the effectiveness of generated textures for a given terrai

Effect of Anions on the Iron Release Pathways of Human Serum Transferrin

Transferrin, the serum iron transport protein in humans, is used to transport 30-40 mg of iron per day through blood. The accessibility of transferrin makes it an attractive target for iron cheating therapeutic agents used in the treatment of iron overload. There is an ongoing search for ligands which can accelerate the rate of iron release, as the currently approved drug DFO has a very slow rate for iron removal. Previous studies have shown that anions can accelerate the rate of iron release. Studies on the effect of anions on the rates of iron release from C-terminal monoferric transferrin at pH 7.4 have been conducted using the ligands acetohydroxamic acid (AHA) and 1,2-dimethyl-3-hydroxy-pyridinone (L1), which follow saturation kinetics, and the ligands, nitrilotriacetic acid (NTA) and diethylenetriaminepentaacetic acid (DTPA), which follow first order kinetics with respect to the ligand concentration. The effects of sulfonates, phosphonates and phosphonocarboxylates have been studied. The anions are divided into two types, simple (non-coordinating) and complex (capable of chelating iron). The simple anions accelerate the rate of iron release, presumably by binding to an allosteric anion binding site on the transferrin. This binding increase the value of kmax for the saturation pathway for AHA and L1 and introduces a kmax for NTA, which otherwise does not have a saturation component. This changes the kinetic behavior of NTA from a strictly first-order dependence on the ligand concentration to complex kinetics, a combination of saturation and first-order kinetics. The complex anions, which can also chelate iron, decrease the rate of iron release by the reference ligands. These anions can also generate a small first order component for iron removal by ligands that normally follow saturation kinetics. These studies emphasize that the appearance of the first order component is due to the replacement of synergistic anion by the incoming chelating ligand and is not an allosteric effect of the anionic ligand. Distinct effects of anions on the saturation and first-order components for iron release are reported. For NTA, the major impact of anions is a decrease in the value of k’

Transformer-Less Cascaded Voltage Source Converter Based STATCOM

In this work, a transformer-less voltage source converter (VSC) based STATCOM is proposed with a combination of cascaded conventional three-phase voltage source inverters. This modular structure provides multilevel operation with reduced switch count and independent DC-link capacitors. The actual contribution of this paper is the transformer-less configuration of a conventional cascaded voltage source converter which provides reduced cost and volume as compared to other transformer-less converter configurations. The system provides reactive power compensation with better power quality when connected to the nonlinear power electronics load also. A simple control system is provided for balancing the Dc link capacitor voltage and reactive power compensation. The validation of the proposed model is analyzed with simulation using MATLAB/SIMULINK software and the results are obtained with different linear and nonlinear load configurations